Stem cell

AVASCULAR NECROSIS
(Osteonecrosis)
TREATMENT
ITRT

Stem cell

AVASCULAR NECROSIS
(Osteonecrosis)
TREATMENT

ITRT

osteo

Avascular Necrosis (Osteonecrosis)
A long-lasting solution for your bones

13

treatments with stem cells

80%

effectiveness

Avascular Necrosis (Osteonecrosis)
A long-lasting solution for your bones

13 |

treatments with stem cells

80% |

effectiveness

What is

avascular necrosis (osteonecrosis)?

What is

avascular necrosis (osteonecrosis)?

Osteonecrosis is a disease caused by the loss of blood flow inside the bones, or ischemia. Without blood flow the tissue dies (necrosis) and the bone weakens.

Osteonecrosis can be caused by a serious illness or trauma, such as a fracture or dislocation, which affects the blood flow to the bone. However, in other cases, it may occur without the cause being known (idiopathic osteonecrosis).

If osteonecrosis occurs near a joint, it can alter it and promote an earlier onset of osteoarthritis. Usually, the affected bones include the hip, shoulder, knee, elbow, wrist and ankle. At first, it does not usually cause any symptoms, but as the disease progresses the joint pain gets worse.

Avascular Necrosis (Osteonecrosis) of the femoral head

Osteonecrosis of the femoral head or hip usually affects people between the ages of 40 and 60.

Although it can be resolved without complication, most patients who progress to hip osteoarthritis will require prosthetic implantation.

Avascular Necrosis (Osteonecrosis) of the femoral head Treatment with expanded mesenchymal stem cells

Avascular Necrosis (Osteonecrosis) of the femoral head Treatment with expanded mesenchymal stem cells

Currently there are different treatments trying to prevent the progression of osteonecrosis. Perforation or forage of the femoral head and neck is a surgical intervention that has proven effective in the early stages for reducing pain and facilitating the formation of new blood vessels in necrotic tissue. However, for many patients, this intervention is not enough, and the disease may progress causing a collapse of the femoral head and osteoarthritis of the joint. In these cases, severe osteoarthritis can develop, requiring a hip prosthesis implant.

The cellular therapy we perform at ITRT consists of a perforation or forage in the femoral head, creating a tunnel where a biograft formed by mesenchymal stem cells and calcium biomaterial is implanted.

Our treatment has been shown to decrease the progression of osteonecrosis, as well as to prevent the collapse of the joint and, in many cases, the need of a prosthesis implantation.

8 out of 10 patients have evolved satisfactorily; their pain has disappeared and they have not required a prosthesis.

This treatment can only be performed in those cases in which the femoral head affected by osteonecrosis still retains its spherical anatomical shape.

Up to now, the processes of bone marrow harvesting and cell inoculation, after the expansion process, have shown that they are safe methodologies, without evidence of adverse effects.

Our process
Stem Cell Osteoarthritis Treatment

  • 01. Assessment

    The medical team assesses the patient and his medical history in order to offer the best solution in each case.

  • 02. Authorisation request to health authorities

    The Spanish Medicine Agency (AEMPS) authorises and controls each treatment.

  • 03. Bone marrow harvesting or adipose tissue obtaining

    Stem cells are obtained by bone marrow harvesting, specifically from the posterior area of the iliac crest bone. It can also be obtained by adipose tissue liposuction.

    Extraction is a minimally invasive procedure that does not require hospitalisation.

    It is performed by local anaesthesia and sedation, and lasts approximately 20-30 minutes.

  • 04. Isolation, culture and expansion of expanded mesenchymal stem cells in the accredited laboratory

    The aspirated sample is sent to the laboratory responsible for selecting adult stem cells, culturing and expanding them.

    For each patient, a dose is prepared according to the indication, and the maximum viability of the cells is guaranteed.

  • 05. Application of expanded mesenchymal stem cells

    Stem cells received from the laboratory are injected into the affected area.

    The application procedure is performed with or without sedation and does not require hospitalisation.

  • 06. Follow-up

    The medical team closely monitors each case to control its evolution.

Our process
Stem Cell Osteoarthritis Treatment

  • 01. Assessment

    The medical team assesses the patient and his medical history in order to offer the best solution in each case.

  • 02. Authorisation request to health authorities

    The Spanish Medicine Agency (AEMPS) authorises and controls each treatment.

  • 03. Bone marrow harvesting or adipose tissue obtaining

    Stem cells are obtained by bone marrow harvesting, specifically from the posterior area of the iliac crest bone. It can also be obtained by adipose tissue liposuction.

    Extraction is a minimally invasive procedure that does not require hospitalisation.

    It is performed by local anaesthesia and sedation, and lasts approximately 20-30 minutes.

  • 04. Isolation, culture and expansion of expanded mesenchymal stem cells in the accredited laboratory

    The aspirated sample is sent to the laboratory responsible for selecting adult stem cells, culturing and expanding them.

    For each patient, a dose is prepared according to the indication, and the maximum viability of the cells is guaranteed.

  • 05. Application of expanded mesenchymal stem cells

    Stem cells received from the laboratory are injected into the affected area.

    The application procedure is performed with or without sedation and does not require hospitalisation.

  • 06. Follow-up

    The medical team closely monitors each case to control its evolution.

Scientific endorsement

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Hello, request an
appointment with us