Pilot study of the electrode-myocardium interface in permanent cardiac stimulation after local application of Platelet-rich plasma

Objectives

This ITRT research line is aimed at generating scientific evidence of the anti-inflammatory and anti-fibrotic effect of LP-PRP on electrode-myocardium interface when applied at the anchoring point of epicardial electrodes.

Methodology

The studies, conducted in canine and pig models, were coordinated by Dr. Joaquim Delclós, a cardiothoracic surgeon at Hospital Ntra. Sra. del Mar de Barcelona, with the participation of the Hospital Clínico Veterinario and the Faculty of Veterinary Medicine of the Universitat Autònoma de Barcelona.

2 pigs and 2 canines were treated. The electrode-myocardium interface of impregnated epicardial electrodes with or without PRP was analysed histologically.

Results

Results showed the potent anti-inflammatory effect of LP-PRP; the fibrosis around the anchor was reduced by half compared to the cases in which PRP was not applied.

Conclusions

The translational interest of these studies lies in the possibility of improving efficacy and considerably extending the life of epicardial pacemakers that are used in paediatrics.


STUDY DESCRIPTION (pig study)
Study in pig animal model
Status:
completed, published
Sponsor: “GUIDANT CORPORATION CARDIAC RHYTHM MANAGEMENT GUIDANT, S.A.”
CEEAH: Hospital Clínico Veterinario (UAB)
Investigators: J Delclòs, C Díaz Bertrana, L Rodríguez, R Soler Rich, I Durall, M Pumarola, Ll Orozco
Participating entities: Servicio de Cardiocirugía. Hospital Ntra. Sra. del Mar. Barcelona; Hospital Clínico Veterinario (UAB); Centre de Teixits i Terapia Cel·lular; ITRT – Centro Médico Teknon; Facultad de Veterinaria (UB)
Funding: Aid to Investigation Fundación Universal

STUDY DESCRIPTION (canine study)
Study in canine animal model
Status:
completed, published
Promotor: “GUIDANT CORPORATION CARDIAC RHYTHM MANAGEMENT GUIDANT, S.A.”
CEEAH: Hospital Clínico Veterinario (UAB)
Investigators: J Delclòs, C Díaz Bertrana, L Rodríguez, R Soler Rich, I Durall, M Pumarola, Ll Orozco
Scientific collaboration: S Vidal, F Vidal
Participating entities: Servicio de Cardiocirugía. Hospital Ntra. Sra. del Mar. Barcelona; Hospital Clínico Veterinario (UAB); Centre de Teixits i Terapia Cel·lular; ITRT- Centro Médico Teknon; Facultad de Veterinaria (UB)
Funding: Aid to Investigation Fundación Universal